Hematopoietic stem cell transplantation for extracranial germ cell tumors

Neysimelia Costa Villela; Patricia Shimoda Ikeuti; Paulo Henrique dos Santos Klinger; Antonella Zanette; Cláudio Galvão de Castro Junior; Luiz Fernando Lopes

doi:10.46765/2675-374X.2025v6n1e291

Hematopoietic stem cell transplantation for extracranial germ cell tumors

Authors

Neysimelia Costa Villela Hospital de Câncer de Barretos – Barretos (SP), Brazil. https://orcid.org/0000-0002-1435-6820
Patricia Shimoda Ikeuti Hospital da Criança de Brasília José de Alencar – Brasília (DF), Brazil. https://orcid.org/0009-0000-1024-0663
Paulo Henrique dos Santos Klinger Associação para Criança e Adolescente com Câncer – Hospital Santa Marcelina – São Paulo (SP), Brazil. https://orcid.org/0000-0001-6739-062X
Antonella Zanette Hospital Erastinho – Curitiba (PR), Brazil|Instituto de Oncologia do Paraná – Curitiba (PR), Brazil. https://orcid.org/0009-0002-2511-7208
Cláudio Galvão de Castro Junior Hemacore – São José dos Campos (SP), Brazil|Certho – Guaratinguetá (SP), Brazil. https://orcid.org/0000-0002-4610-8282
Luiz Fernando Lopes Hospital de Câncer de Barretos – Barretos (SP), Brazil. https://orcid.org/0000-0001-9737-9245

DOI:

https://doi.org/10.46765/2675-374X.2025v6n1e291

Keywords:

Neoplasms, Germ Cell and Embryonal, Stem Cell Transplantation, Pediatrics

Abstract

Malignant extracranial germ cell tumors (GCT) are uncommon in the pediatric population. Most affected children can achieve cure using conventional chemotherapy combined with appropriate local control. The role of high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT) in GCT has been studied mainly in adult cohorts. In this article, we reviewed the current evidence and indications for HDCT/ASCT in the management of pediatric GCT.

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11/26/2025

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Villela, N. C., Ikeuti, P. S., Klinger, P. H. dos S., Zanette, A., Castro Junior, C. G. de, & Lopes, L. F. (2025). Hematopoietic stem cell transplantation for extracranial germ cell tumors. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 6(1). https://doi.org/10.46765/2675-374X.2025v6n1e291

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Hematopoietic stem cell transplantation for extracranial germ cell tumors

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