Leucemia mielóide aguda em crianças e adolescentes em instituições Brasileiras: realidade e desafios

Authors

  • Ana Luiza de Melo Rodrigues Department of Pediatric Oncology and Bone Marrow Transplant, Erasto Gaertner Hospital, Curitiba – PR, Brazil https://orcid.org/0000-0002-2346-7194
  • Luana Lenzi Department of Clinical Analysis, Federal University of Paraná, Curitiba - PR, Brazil https://orcid.org/0000-0002-4829-1703
  • Lisa Lee-Jones Department of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom https://orcid.org/0000-0003-1255-3545
  • Alayde Vieira Wanderley Department of Pediatric Oncology, Hospital Oncológico Octávio Lobo, Belém – PA, Brazil
  • Ana Maria Marinho Da Silva Department of Pediatric Oncology, Aristides Maltez Hospital, Salvador – BA, Brazil
  • Cinthya Rocha De Carvalho Department of Pediatric Oncology, Institute of Integral Medicine Professor Fernando Figueira – IMIP, Recife – PE, Brazil
  • Juliana Teixeira Costa Department of Pediatric Oncology, Martagão Gesteira Hospital, Salvador – BA, Brazil
  • Cláudio Galvão De Castro Junior Department of Pediatric Oncology, Santo Antonio Children's Hospital, Porto Alegre – RS, Brazil
  • Maria Lucia De Martino Lee Brazilian Childhood Leukemia Treatment Group (GBTLI) - Coordinator
  • Mecneide Mendes Lins Department of Pediatric Oncology, Institute of Integral Medicine Professor Fernando Figueira – IMIP, Recife – PE, Brazil
  • Patrick Rezende Godinho Department of Pediatric Oncology, Fundação Pio XII - Amor da Amazônia Hospital, Porto Velho – RO, Brazil
  • Raul Correa Ribeiro Department of Oncology and Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis - TN, USA https://orcid.org/0000-0002-9956-5647

DOI:

https://doi.org/10.46765/2675-374X.2020v2n1p77-86

Keywords:

Pediatric AML. HSCT. Brazil

Abstract

Objective: To describe the outcome of acute myeloid leukemia (AML) among children treated in Brazilian institutions. Methods: A structured online questionnaire was sent to pediatric oncologists affiliated to the Brazilian Society of Pediatric Oncology. The physicians and institutions were unidentified. Results: One hundred and four pediatric oncologists in all Brazilian regions answered the questionnaire. The treatment-related mortality rate was reported to be higher than 30% by 29.8% of the participants. Difficulty in accessing the intensive care unit (ICU) was reported by 54.8%. About 85% had access to cytogenetics, 78% to molecular testing, 94% to the measurement of residual disease by flow cytometry. About 90% of participants reported access to HSCT, but 86% of them had difficulties in providing HSCT timely. About 95% of the respondents indicated the need to create a national treatment protocol, and 89.4% are willing to collaborate with a national study group. Conclusion: Our study demonstrated large gaps in the treatment of pediatric AML in Brazil. To improve outcome, a national protocol will have to consider the regional differences and adapt the management according to the local resources.

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Published

10/14/2020

How to Cite

de Melo Rodrigues, A. L., Lenzi, L., Lee-Jones, L., Vieira Wanderley, A., Marinho Da Silva, A. M., Rocha De Carvalho, C., … Correa Ribeiro, R. (2020). Leucemia mielóide aguda em crianças e adolescentes em instituições Brasileiras: realidade e desafios. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 1(3), 77–86. https://doi.org/10.46765/2675-374X.2020v2n1p77-86

Issue

Vol. 1 No. 3 (2020): Journal of Bone Marrow Transplantation and Cellular Therapy

Section

Original article

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