C- reactive protein in autologous stem cell transplantation: prediction of clinical complication

Bruna Sabioni; Eduardo Edelman Saul; Rodrigo Portugal; Marcia Rejane Valentim; Angelo Maiolino; Marcia Garnica

doi:10.46765/2675-374X.2021v2n2p44

C- reactive protein in autologous stem cell transplantation: prediction of clinical complication

Authors

Bruna Sabioni Universidade Federal do Rio de Janeiro
Eduardo Edelman Saul Universidade Federal do Rio de Janeiro
Rodrigo Portugal Universidade Federal do Rio de Janeiro
Marcia Rejane Valentim Complexo Hospitalar de Niteroi
Angelo Maiolino Universidade Federal do Rio de Janeiro
Marcia Garnica Universidade Federal do Rio de Janeiro

DOI:

https://doi.org/10.46765/2675-374X.2021v2n2p44

Keywords:

autologous stem cell transplant; febrile neutropenia; complication; C-reactive protein; mucositis

Abstract

Objective: The aim of this study was to evaluate C-reactive protein (CRP) as a predictor of complications during autologous stem cell transplant (HSCT). Methods: We analyzed a cohort of 340 transplants. Correlation analyses were performed, including CRP obtained before HSCT, on Day+3, Day+6, Day+9, after Day+11, and at the onset of febrile neutropenia, and the following outcomes: bacteremia, severity of mucositis, length of neutropenia and hospitalization, and death. Results: the median age was 54 years old (ranging from 20 to 75), and 62% and 20% were multiple myeloma and non-Hodgkin lymphoma cases, respectively. The median CRP levels increased from D+3 to D+9 and after that decreased progressively until discharge. CRP levels were associated with bacteremia, mucositis grade, length of neutropenia and hospitalization, and death. Variation in CRP values from D+3 to D+6 predicted complications. Mortality was associated with D+9 CRP levels (19 vs. 7.9 mg/dL; p<0.01), and a ROC curve area of 0.83 (95% CI 0.7 – 0.95) to predict mortality. At a cut-off of 8.5mg/dL, D+9 CRP had 83% and 79% sensitivity and specificity, respectively.

Conclusions: In this study, CRP dynamics were associated with several HSCT complications. CRP levels curve could be applied to indicate poor outcomes during HSCT.

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Published

07/14/2021

How to Cite

Sabioni, B., Saul, E. E., Portugal, R., Valentim, M. R., Maiolino, A., & Garnica, M. (2021). C- reactive protein in autologous stem cell transplantation: prediction of clinical complication. JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY, 2(2), p44. https://doi.org/10.46765/2675-374X.2021v2n2p44

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Issue

Vol. 2 No. 2 (2021): Journal of Bone Marrow Transplantation and Cellular Therapy

Section

Original article

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